In an old StarTrek episode the robot Nomad sailed the universe seeking life, and upon finding it, implemented the fatal PrimeDirective. It is imperative that our organizational mission statements comply with a negative PrimeDirective, which may be stated: "It is our mission to improve the conditions for life, to grow in the ability to nurture life, and to explore all realms possibly related to life, universally seeking to sustain biological diversity, to increase individual personal fulfillment, and to create a more stable, peaceful, and just society.
Already-proven engineering and ethical principals need to a greater degree be incorporated into the decision-making process. In particular, given its promise of finding optimal solutions, it is key that Nash Equilibrium models are used to form the daily decisions that determine how limited resources are spent, thus optimizing scientific research and economic prosperity. Great care must be made in structuring and reviewing the decision-making and implementation processes so that they, to borrow from perl philosophy, "do the right thing", quantifying and transparently reporting each step along the way, and flexibly accepting feedback without losing sight of the overall goal. It is a challenge and responsibility to build such a system, and we are fortunate that John Nash has already blazed the trail.